301 Acadia Avenue, Former Brame’s Grocery and Crown Drugs, c. 1916, remodeled in the 1960s (non-contributing)

This corner has always been a commercial area in the neighborhood. Originally, a frame store owned by C. D. Couch housed Southside Grocery on the first floor with a private school run by Mrs. Poindexter above it. Maurice M. Brame bought the building in December 1916 and opened Brame's Grocery. At some point, he demolished the frame building and built the current structure with four sections, three of which face Hollyrood Street and a small fourth portion facing Acadia which housed Smith's, later Cooper's, Barber Shop. At the corner was a drugstore (at one point Swainey Drugs), west was Mr. Brame's grocery store, and to the north was a storage area.

In 1935 the building was bought by brothers Wade and Arthur Stonestreet. They had begun Sampson Medicine Company, a wholesaler of patent medicine and neighborhood pharmacy with novelty items, on Waughtown Street in 1920, then moved to this location in 1935. (The Stonestreets also built an office addition to the north at 2002 Hollyrood Street.) In 1946, pharmacist John Causey opened Causey's Pharmacy in the southern section, which had been a drugstore since at least 1932 and where Causey had worked. In 1947, he hired Conrad Stonestreet (Wade's son) to work in the soda shop, soon sold him a 10% interest in the pharmacy, and eventually the entire ownership.

In 1950 Conrad changed the name to Acadia Pharmacy and by 1955 had expanded to include the middle section of the building. Wade Stonestreet died in 1955 and the family sold his interest in Sampson Medicine Company (in the northern section) to a cousin, Ashley Stonestreet. By 1960, Conrad Stonestreet had expanded Acadia Pharmacy to all sections of the building, and by 1964, he had acquired four stores. Conrad then renamed the company Crown Drugs with this store becoming Crown-Acadia. There were eventually 19 Crown Drugstores, which were bought by the Eckerd Corporation in 1994.